Longitudinal qualitative exploration of cancer information-seeking experiences across the disease trajectory: the INFO-SEEK protocol

Introduction Α substantial corpus of literature has sought to describe the information-seeking behaviour of patients with cancer. Yet, available evidence comes mainly from cross-sectional studies, which provide ‘snapshots’ of patients’ information needs and information-seeking styles at a single time point. Only a few longitudinal studies currently exist; however, these are quantitative in nature and, despite successfully documenting changes in patients’ information needs throughout the clinical course of cancer, they have failed to provide an evidence-based interpretation of the causes and consequences of change. The goal of this study is threefold: First, we wish to provide a holistic understanding of how cancer information-seeking behaviour may evolve across different stages of the patient journey. Second, we will seek to elucidate the contextual and intervening conditions that may affect possible changes in information seeking. Third, we will attempt to identify what the consequences of these changes are, while heightening their implications for clinical practice and policy. Methods and analysis We will carry out a longitudinal qualitative study, based on face-to-face, in-depth interviews with approximately 25 individuals diagnosed with cancer. Patients will be recruited from 2 oncology hospitals located in Ticino, Switzerland, and will be interviewed at 3 different time points: (1) within 2 weeks after receiving the cancer diagnosis; (2) within 2 weeks after their initial treatment; and (3) 6 months after their initial treatment. All interviews will be recorded and transcribed verbatim. A grounded theory approach will be used for the analysis of the data. Ethics and dissemination The study protocol has been approved by the Ethics Committee of Canton Ticino (CE 2813). Participation in the study will be voluntary, and confidentiality and anonymity ensured. Prior to study participation, patients will be asked to provide signed informed consent. Findings will be disseminated in international peer-reviewed journals and presented in relevant conferences

Protons at the Gate DEG/ENaC Ion Channels Help Us Feel and Remember

AbstractThe DEG/ENaC ion channel family contributes to channels of striking functional diversity. Neuronally expressed family members include the C. elegans degenerins that mediate touch and are thought to be mechanically gated, and the mammalian ASICs, which are gated by protons. ASICs affect a range of sensory functions that includes perception of gentle touch, harsh touch, heat, sour taste, and pain. Family member ASIC1 is now implicated in long-term potentiation, suggesting that minute fluxes in synaptic pH may activate ASICs to enhance learning

Computational analysis reveals increased blood deposition following repeated mild traumatic brain injury.

Mild traumatic brain injury (mTBI) has become an increasing public health concern as subsequent injuries can exacerbate existing neuropathology and result in neurological deficits. This study investigated the temporal development of cortical lesions using magnetic resonance imaging (MRI) to assess two mTBIs delivered to opposite cortical hemispheres. The controlled cortical impact model was used to produce an initial mTBI on the right cortex followed by a second injury induced on the left cortex at 3 (rmTBI 3d) or 7 (rmTBI 7d) days later. Histogram analysis was combined with a novel semi-automated computational approach to perform a voxel-wise examination of extravascular blood and edema volumes within the lesion. Examination of lesion volume 1d post last injury revealed increased tissue abnormalities within rmTBI 7d animals compared to other groups, particularly at the site of the second impact. Histogram analysis of lesion T2 values suggested increased edematous tissue within the rmTBI 3d group and elevated blood deposition in the rm TBI 7d animals. Further quantification of lesion composition for blood and edema containing voxels supported our histogram findings, with increased edema at the site of second impact in rmTBI 3d animals and elevated blood deposition in the rmTBI 7d group at the site of the first injury. Histological measurements revealed spatial overlap of regions containing blood deposition and microglial activation within the cortices of all animals. In conclusion, our findings suggest that there is a window of tissue vulnerability where a second distant mTBI, induced 7d after an initial injury, exacerbates tissue abnormalities consistent with hemorrhagic progression

On Projected Solutions for Quasi Equilibrium Problems with Non-self Constraint Map

In a normed space setting, this paper studies the conditions under which the projected solutions to a quasi equilibrium problem with non-self constraint map exist. Our approach is based on an iterative algorithm which gives rise to a sequence such that, under the assumption of asymptotic regularity, its limit points are projected solutions. Finally, as a particular case, we discuss the existence of projected solutions to a quasi variational inequality problem.Comment: 18 page

From the emotional integration to the cognitive construction: the developmental approach of Turtle Project in children with autism spectrum disorder

Background: Children with autism spectrum disorder show a deficit in neurobiological processes. This deficit hinders the development of intentional behavior and appropriate problem-solving, leading the child to implement repetitive and stereotyped behaviors and to have difficulties in reciprocal interactions, empathy and in the development of a theory of mind. The objective of this research is to verify the effectiveness of a relationship-based approach on the positive evolution of autistic symptoms. Method: A sample of 80 children with autism spectrum disorder was monitored during the first four years of therapy, through a clinical diagnostic assessment at the time of intake and then in two follow-up. Results: The results showed that through the Autism Diagnostic Observation Schedule it is possible to assess the socio-relational key elements on which the therapy is based. There was evidence, in fact, of significant improvements after two and four years of therapy, both for children with severe autistic symptoms and for those in autistic spectrum. Conclusions: Socio-relational aspects represent the primary element on which work in therapy with autistic children and can be considered as indicators of a positive evolution and prognosis that will produce improvements even in the cognitive are

The emotional contagion in children with autism spectrum disorder

Studies of the last decade have demonstrated that children with Autism Spectrum Disorder (ASD) showed difficulties in language, social and relational areas, but they had also impairment in the mechanisms of embodied simulation, namely the imitative behaviors that allow the body to give an experiential meaning to own and other’s emotions. The identification of this specific emotional response in ASD children, also defined as emotional contagion, allows to move the therapeutic focus from reducing the behavioral symptomatic expressions of the child to promoting the expression of his ability of emotional regulation. The aim of this study was to investigate the presence of emotional contagion in 53 ASD children aged between 22 and 66 months, through the Test of emotional contagion and verify the presence of compromised emotional contagion areas. Our findings have shown that the severity of the disorder is closely related to the inability of the child to respond to the emotional stimuli, regardless from cognitive abilities, and that emotion to which children responded most frequently was happiness, while the one who responded less was anger

Influence of Local Pressures on Maldivian Coral Reef Resilience Following Repeated Bleaching Events, and Recovery Perspectives

Two severe heat waves triggered coral bleaching and mass mortality in the Maldives in 1998 and 2016. Analysis of live coral cover data from 1997 to 2019 in shallow (5 m depth) reefs of the Maldives showed that the 1998 heat wave caused more than 90% of coral mortality leaving only 6.8 ± 0.3% of survived corals in all the shallow reefs investigated. No significant difference in coral mortality was observed among atolls with different levels of human pressure. Maldivian reefs needed 16 years to recover to the pre-bleaching hard coral cover values. The 2016 heat wave affected all reefs investigated, but reefs in atolls with higher human pressure showed greater coral mortality than reefs in atolls with lower human pressure. Additionally, exposed (ocean) reefs showed lower coral mortality than those in sheltered (lagoon) reefs. The reduced coral mortality in 2016 as compared to 1998 may provide some support to the Adaptive Bleaching Hypothesis (ABH) in shallow Maldivian reefs, but intensity and duration of the two heat waves were different. Analysis of coral cover data collected along depth profiles on the ocean sides of atolls, from 10 to 50 m, allowed the comparison of coral mortality at different depths to discuss the Deep Refuge Hypothesis (DRH). In the upper mesophotic zone (i.e., between 30 and 50 m), coral mortality after bleaching was negligible. However, live coral cover did not exceed 15%, a value lower than coral survival in shallow reefs. Low cover values of corals surviving in the mesophotic reefs suggest that their role as refuge or seed banks for the future recovery of some species in shallow-water reefs of the Maldives may be small. The repeatedly high coral mortality after bleaching events and the long recovery period, especially in sites with human pressure, suggest that the foreseen increased frequency of bleaching events would jeopardize the future of Maldivian reefs, and ask for reducing local pressures to improve their resilience